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Glycine: how much to take

Glycine is a simple amino acid your body also makes. It is sold mainly for sleep, as a cheap powder with a sweet taste.

Calculator Official intake Study doses Best form Safety Sources

Adults 18+ only
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Official daily intake

Glycine is not an essential nutrient, so there is no official daily intake. Only study doses are shown.

Doses used in studies

These are doses tested in research, not personal advice. Some exceed the upper limit because they were short courses or given under medical care.

Weak evidenceWeak: one small trial, pilot data or results that conflict.Based on 2 randomised trials.How grades work

Better sleep quality and less next-day tiredness

3 g a day

Small Japanese trials gave 3 g glycine before bed. People reported better sleep, and sleep recordings changed in one study. After nights of shortened sleep, glycine reduced daytime sleepiness and fatigue. Studies were small and short.

Yamadera W et al. 2007 · Bannai M et al. 2012

Best form and why

Practical pick

Glycine powder or capsules (g)

Why: Plain glycine powder is cheap and dissolves in water; 3 g is about a level teaspoon.

Alternatives: Capsules are handy but usually hold under 1 g each, so you need several.

Yamadera W et al. 2007

Food sources

Gelatin, bone broth, meat, fish, legumes.

Interactions

Avoid with the antipsychotic clozapine. Otherwise few known interactions.

Safety

Well tolerated at a few grams a day; large doses can upset the stomach.

Pregnant, breastfeeding, on medication, or managing a health condition? Check with a doctor or pharmacist before starting a supplement.

Sources

  1. Randomised trial Yamadera W et al. (2007). Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes. Sleep Biol Rhythms
  2. Randomised trial Bannai M et al. (2012). The Effects of Glycine on Subjective Daytime Performance in Partially Sleep-Restricted Healthy Volunteers. Front Neurol 3:61

Values checked: November 12, 2026.

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