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Multivitamin: how much to take

A multivitamin combines many vitamins and minerals in one pill. Enter what your label says to see how it adds up, and whether anything is too high or missing.

Calculator Official intake Study doses Best form Safety Sources

Adults 18+ only
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Official daily intake

A multivitamin is checked nutrient by nutrient. Enter each amount from your label.

Doses used in studies

These are doses tested in research, not personal advice. Some exceed the upper limit because they were short courses or given under medical care.

Moderate evidenceModerate: smaller trials, mixed results or official guidance.Based on 1 randomised trial.How grades work

Cancer prevention in older men

No single dose

Physicians' Health Study II: 14,641 male doctors aged 50 and over took a daily multivitamin or placebo for about 11 years. Total cancer was 8% lower (17.0 against 18.3 cases per 1,000 person-years). No single cancer type and no cancer deaths were significantly reduced.

Gaziano JM et al. 2012

Strong evidenceStrong: meta-analyses of randomised trials or a large trial, with results that agree.Based on 1 randomised trial.How grades workNo benefit or harm found

Cancer and heart disease in older adults

No single dose

COSMOS: 21,442 adults aged 60 and over took a daily multivitamin or placebo for a median of 3.6 years. There was no effect on total cancer, heart disease or deaths.

Sesso HD et al. 2022

Moderate evidenceModerate: smaller trials, mixed results or official guidance.Based on 1 meta-analysis.How grades work

Memory in older adults

No single dose

Three COSMOS sub-studies found a small benefit for overall thinking and episodic memory with a daily multivitamin over 2 to 3 years, which the authors equate to about 2 years less cognitive ageing.

Vyas CM et al. 2024

Best form and why

No best form

Why: Look for amounts close to the daily intake rather than mega-doses, B6 at or below 12 mg, no iron unless you need it, and iodine, vitamin D and B12 included.

US Preventive Services Task Force 2022 · EFSA 2025

Food sources

A varied diet with vegetables, fruit, whole grains, dairy or alternatives, and protein foods covers most needs.

Interactions

Check each nutrient against your other products: zinc, vitamin A, B6, iron and iodine add up fastest.

Safety

The US Preventive Services Task Force found the evidence insufficient to recommend multivitamins for preventing heart disease or cancer, and advises against beta-carotene and vitamin E supplements for that purpose.

Pregnant, breastfeeding, on medication, or managing a health condition? Check with a doctor or pharmacist before starting a supplement.

Sources

  1. Official reference EFSA NDA Panel (2016). Dietary reference values for vitamin D. EFSA Journal
  2. Official reference EFSA (2025). Overview on Tolerable Upper Intake Levels as derived by the SCF and the EFSA NDA Panel (version 11, August 2025). EFSA
  3. Official reference National Academies (NASEM) (2019). Dietary Reference Intakes: RDA, AI and UL tables (via NIH ODS Nutrient Recommendations). Food and Nutrition Board
  4. Official reference EFSA (2017). Dietary Reference Values for nutrients: Summary report. EFSA Supporting Publications
  5. Official reference EFSA NDA Panel (2024). Scientific opinion on the tolerable upper intake level for iron. EFSA Journal 22(6):e8819
  6. Official reference EFSA NDA Panel (2015). Scientific Opinion on Dietary Reference Values for vitamin E as alpha-tocopherol. EFSA Journal 13(7):4149
  7. Official reference EFSA (2015). Dietary reference values: magnesium and phosphorus. EFSA news
  8. Official reference EFSA NDA Panel (2017). Dietary reference values for vitamin K. EFSA Journal 15(5):4780
  9. Official reference EFSA NDA Panel (2016). Dietary Reference Values for choline. EFSA Journal 14(8):4484
  10. Official reference NIH Office of Dietary Supplements (2026). Copper: fact sheet for health professionals (checked November 2026). NIH ODS
  11. Official reference CDC (2026). National Report on Biochemical Indicators of Diet and Nutrition: Trace elements, copper. CDC
  12. Official reference NIH Office of Dietary Supplements (2026). Manganese: fact sheet for health professionals (checked November 2026). NIH ODS
  13. Official reference NIH Office of Dietary Supplements (2026). Chromium: fact sheet for health professionals (checked November 2026). NIH ODS
  14. Official reference NIH Office of Dietary Supplements (2026). Molybdenum: fact sheet for health professionals (checked November 2026). NIH ODS
  15. Official reference NIH Office of Dietary Supplements (2026). Phosphorus: fact sheet for health professionals (checked November 2026). NIH ODS
  16. Randomised trial Gaziano JM et al. (2012). Multivitamins in the prevention of cancer in men: the Physicians' Health Study II randomized controlled trial. JAMA 308:1871-1880
  17. Randomised trial Sesso HD et al. (2022). Multivitamins in the prevention of cancer and cardiovascular disease: the COSMOS randomized clinical trial. Am J Clin Nutr 115:1501-1510
  18. Meta-analysis Vyas CM et al. (2024). Effect of multivitamin-mineral supplementation versus placebo on cognitive function: COSMOS clinic subcohort and meta-analysis of 3 cognitive studies. Am J Clin Nutr 119:692-701
  19. Official reference US Preventive Services Task Force (2022). Vitamin, mineral, and multivitamin supplementation to prevent cardiovascular disease and cancer: recommendation statement. JAMA 327:2326-2333

Values checked: November 12, 2026.

Fact sheets on other sites

Independent summaries to read alongside this page. PillMath is not affiliated with these sites.

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